Sirimanne, N. LRodrigo,U. A. AJayakody, R.S2026-09-302026-09-302026-05-021012-8999https://dr.ichemc.ac.lk/handle/123456789/551Abstract No: 2025_425 Page No 88Cardiovascular disease remains a leading cause of global mortality, with hypercholesterolemia identified as a major modifiable risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol by binding to the EGF-A domain of the low-density lipoprotein receptor (LDLR), promoting its degradation and thereby reducing LDL-cholesterol clearance.enThymoquinonePCSK9LDLRmolecular dockingmolecular dynamicsArticle