Browsing by Author "Rodrigo,U. A. A"

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    In silico modelling of thymoquinone disruption of PCSK9-LDLR binding for cholesterol regulation
    (Institute Of Chemistry Ceylon, 2026-05-02) Sirimanne, N. L; Rodrigo,U. A. A; Jayakody, R.S
    Cardiovascular disease remains a leading cause of global mortality, with hypercholesterolemia identified as a major modifiable risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol by binding to the EGF-A domain of the low-density lipoprotein receptor (LDLR), promoting its degradation and thereby reducing LDL-cholesterol clearance.