Modulation in the Structure, Dynamics, and Enzymatic Activity of an Ordered Protein β-Lactoglobulin through Liquid-Liquid Phase Separation

Abstract

Bimolecular condensates formed through liquid–liquid phase separation (LLPS) of proteins, polypeptides, and nucleic acids have garnered significant research of late.1-3 Despite valuable contributions of prior research, there is untapped potential in exploring the influence of phase separation on the conformational dynamics and enzymatic activities of native proteins.