Abstract
Permanent URI for this collectionhttps://dr.ichemc.ac.lk/handle/123456789/82
Browse
Recent Submissions
Item Feasibility study of 64Cu production using neutron activation for potential application in Positron Emission Tomography (PET) in Sri Lanka(Institute of Chemistry Ceylon, 2022-06) Dilukshi,E. G. M; Sumithrarachchi,C. S; Lamabadusuriya,M. R.Among various medical imaging techniques, Positron Emission Tomography (PET) is increasingly being used in medical diagnosis. However, PET scanning is quite expensive owing to the difficulties in manufacturing radioactive tracer.Item Cinnamomum zeylanicum Blume post distillation waste mediated fabrication of silver nanoparticles and evaluation of their antibacterial activities(Institute of Chemistry Ceylon, 2022-06) Lokuge,C. M; Ranasinghe,P; H. D. Weerathunge; Premakumara,G. A. S; Premakumara,G. A. SResiduals and unrecovered oils, including hydrosols, enriched in phenolic compounds are discarded as waste during the cinnamon bark oil extraction process in Sri Lanka.Item Characterization of BSA nanoparticles loaded with bioactive compounds present in the quills of C. zeylanicum as an antidiabetic nutraceutical(Institute of Chemistry Ceylon, 2022-06) Wanniarachchi,B. S; Sathsarani,H. M. W. K; Jayawardena,B. MDiabetes mellitus is the most common noncommunicable disease and the ninth leading cause of death in the world. Oral antidiabetic drugs have serious side effects and therefore, about 60% of the world’s population currently uses traditional medicine in the treatment of diabetes as the side effects are less.Item Effect of plant extracts from Plectranthus amboinicus, Moringa oleifera and Ocimum sanctum Linn as a natural inhibitor on oxidation of fish oil(Institute of Chemistry Ceylon, 2022-06) Shanuke,D. S; Marapana,R. A. U. J; Hettiarachchi,S; Edirisinghe,E. M. R. K. BPolyunsaturated fatty acids present in fish oil (FO) are highly susceptible to oxidation. Natural and synthetic antioxidants are effectively applied to stabilize FO against oxidation. This study was focused to evaluate the synergistic antioxidant effect of three plant extracts (1% w/v) prepared from Plectranthus amboinicus (Country borage, K), Moringa oleifera (Drumstick, M) and Ocimum sanctum Linn (Tulsi, T).Item Two Potentially Wound Healing Active Compounds from the Hexanes Extract of Vernonia zeylanica (L.) Less(Institute of Chemistry Ceylon, 2022-06) Samarasinghe,W. M. Priyantha; Ranasinghe,C; Jayawardana,K. H; Somaratne,S; Gunaherath,G. M. Kamal. BVernonia zeylanica (L.) Less. (Asteraceae) is an under-shrub endemic to Sri Lanka. Different parts of this plant have been used as a remedy for various kinds of wounds in the indigenous medicine practiced in Sri Lanka.Item Extraction, analysis, and comparison of volatile oils from leaves and fruit peels of Citrus sinensis by using two different extraction techniques(Institute of Chemistry Ceylon, 2022-06) Jagoda,D; Liyanaarachchi,G. D; Weeratunge,H. D; Handunnetti,Shiroma. M; Samarasekara,J. K. R. REssential oils from the Citrus family are commonly used in aromatherapy, to relieves anxiety and pain. In the traditional systems of medicine, it is also used as an anti-inflammatory and antiseptic agent. Microwaveassisted hydro-distillation (MAHD) is a modern technique which uses the microwave for the extraction of essential oils from aromatic and medicinal plants.Item Risk-benefit analysis of heavy metals and fatty acids in selected food fish of Sri Lanka(Institute of Chemistry Ceylon, 2022-06) Jayakody,J. A. K. S; Senevirathne,S. A; Senarathna,L; Edirisinghe,E. M. R. K. BBeneficial effects on human health by consumption of omega-3 fatty acids may be challenged by the presence of heavy metals (HMs) in fish. This study focused on comparing fatty acid composition (FAC) and HMs in fish lipids (FL) of twenty-seven fish species (N=2) from Trincomalee and quantitative estimation of the risk -benefit.Item Utilization of synthetic silica and cross-linked polymethyl methacrylate (PMMA) as anti-block agents and evaluating their influence on desirable physical properties of power cables(Institute of Chemistry Ceylon, 2022-06) Premathilaka,H. M. B; Prashantha,M. A. B; Arunajith,R. A. P; Karunarathna,B. S. WA cable is composed of three major components, namely, conductor, insulation, and jacket. Copper and aluminium are widely employed as conductors in cables. PVC is a popular insulating material, which offers outstanding resistance to a wideItem Acetylcholinesterase inhibitory activity of Psychotria sarmentosa, Olax zeylanica and Hoya ovalifolia(Institute of Chemistry Ceylon, 2022-06) De Silva,W. S; Wijayarathna, C. D; De Silva,H. I. CAlzheimer’s disease is the most prevailing neurodegenerative disease and is becoming one of the major human health concerns today. Medicinal plants are known to produce a broad range of bioactive compounds and thus become an excellent source for the discovery of novel anti-acetylcholinesterase active drugs.Item Exploring in vitro antioxidant and anti-inflammatory activities of fresh fruit of Garcinia quaesita(Institute of Chemistry Ceylon, 2022-06) Ekanayaka,K. S. J; Gunaratna,M. JGarcinia quaesita which is locally referred to as “Rath Goraka”, is an endemic species growing wild in the wet and intermediate zones of Sri Lanka. This species has been in use for a long period of time in Sri Lankan traditional medicine to treat various disease conditions.Item Determination of cytotoxicity of some selected marine sponge extracts of Sri Lanka against the histiocytic human lymphoma cell line U-937(Institute of Chemistry Ceylon, 2022-06) Kosgahakumbura,L. N; Muhammad,Taj; Gamage,J.B; Gunasekera,S; Cárdenas,P; Jayasinghe,R. P. P. K; Hettiarachchi,C. MWith the rapid emergence of cancerous diseases worldwide and the adverse side effects of existing therapeutics, discovering novel candidates from potential sources is critical. In this respect, marine sponges are a promising natural resource of anticancer compounds.Item Marine sponge Axinella donnani as a potential drug source(Institute of Chemistry Ceylon, 2022-06) Gamage,Jayani; Kosgahakumbura,L. N; Gunasekera,S; Cárdenas,P; Jayasinghe,R. P. P. K; Hettiarachchi,C. MAxinella donnani is a marine sponge from the Axinellidae family known to have structurally unique and bioactive metabolites.Item Development and validation of new method for the simultaneous determination of Clotrimazole and Beclomethasone Dipropionate by HPLC in topical cream formulation(Institute of Chemistry Ceylon, 2022-06) Gunasekera,S; Fernando,SNew topical cream formulations for dermatological treatment against broad spectrum antimycotic agent and various inflammatory conditions contain a combination of Clotrimazole (CT) and Beclomethasone Dipropionate (BD).Item Removal of toluene in an intramural environment using Sansevieria trifasciata(Institute of Chemistry Ceylon, 2022-06) Gunasinghe,Y. H. K. I. S; Rathnayake, I. V. N; Deeyamulla,M. PVolatile Organic Compounds (VOCs) are a group of chemicals that can be emitted as gasses into indoor air at room temperature. Benzene, toluene, ethylbenzene, and xylene are the most common hazardous VOCs that persist in indoor air.Item Method validation for the determination of Chloramphenicol, a banned veterinary antibiotic in shrimps, by using liquid chromatography-tandem mass spectroscopy(Institute of Chemistry Ceylon, 2022-06) Manamperi,D. C. P; Malavipathirana,SChloramphenicol is one of the most widely used antibiotics for both food and domestic animals. It is a broad spectrum antibiotic which interferes with protein synthesis of many Gram-negative and Gram-positive bacteria and has toxic effects on human.Item Modified copper-based metal-organic frameworks as novel photoanode material(Institute of Chemistry Ceylon, 2022-06) Abeysingha,S. N; Perera,I. R; Hettiarachchi,C. VMetal Organic Frameworks (MOFs) are highly porous, crystalline, and well-ordered organicinorganic hybrid channel structures.Item Pyrolysis of waste polypropylene to fuel oil(Institute of Chemistry Ceylon, 2022-06) Uthpalani,P. G. I; Premachandra,J. K; Weerasinghe,V. P. A; De Silva,D. S. MPlastic waste accumulation in the environment has increased rapidly. This is mainly due to their versatile properties, which allow them to be used as substitutes for wood, metals, ceramics, and glass.Item Parameter Optimization and Kinetics Modeling for Biosorption of Methylene Blue Dye on Artocarpus nobilis Fruit Peel(Institute of Chemistry Ceylon, 2022-06) Samaraweera,A. P. G. M. V; Priyantha,NDye removal through biosorption has not been extensively investigated at the industrial level, partly due to the lack of correlation between laboratory findings and requirements of large-scale applications.Item In silico study on thermal decomposition of polystyrene tetramer model compound(Institute of Chemistry Ceylon, 2022-06) Wanniarachchi,J. D; Prashantha,M. A. B; Karunarathna,B. S. WThe studies on the pyrolysis processes aid the development and use of pyrolysis technology for waste plastics. The present study investigated the thermal decomposition mechanism of the tetramer model compound of polystyrene by employing the density functional theory method at B3LYP/6-31G (d) level of theory.Item In-silico investigation on derivatives of (Z)-N-phenyl acetamidoximes as potential inhibitors against Helicobacter pylori(Institute of Chemistry Ceylon, 2022-06) Dissanayaka,D. M. P. M; Gunaratna,M. JHelicobacter pylori is a major cause of gastrointestinal diseases, including gastritis, gastric and duodenal ulceration, gastric carcinoma, and gastric cancer. Urease enzyme secreted by H. pylori, hydrolyses urea, generating ammonia which neutralizes stomach acid and create a suitable pH environment to the bacterium to survive and colonize in the stomach.