T he inhibition of acetylcholinesterase via synthetically viable coumarin derivatives

Abstract

Acetylcholinesterase is a serine hydrolase responsible for the hydrolysis of acetylcholine. The reversible inhibition of acetylcholinesterase can be useful in combating Alzheimer’s disease (AD). A computational study of the inhibition of acetylcholinesterase was conducted by performing Molecular Docking using a series of coumarin analogs generated by fragment based drug design methods.