Browsing by Author "Udawatte,C.S"
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Item A computational study on the inhibition of MCL-1 anti-apoptotic protein to activate apoptosis in cancer cells via commercially available natural product derivatives(Institute of Chemistry Ceylon, 2019-05) Costa,M.S.V; Ratnaweera,C.N; Udawatte,C.SBcl-2, BCL-XL and MCL-1 (Myeloid cell leukemia-1) are important anti-apoptotic proteins. The objective of this research was to identify commercially available natural product derivatives to inhibit MCL-1. Ligands were obtained from the ZINC12 database which provides 30793 chemically modified, commercially available natural product derivatives.Item Cinnamon wood as an adsorbant for the removal of Cu2+ from aqueous solutions(Institute of Chemistry Ceylon, 2019-05) Wijesekara,D.N; Udawatte,C.SHeavy metal water pollution remains one of the most harmful ecological and health issues globally, and Cu2+ is a common pollutant found in water bodies. Cinnamon (Cinnamomum verum or Cinnamomum zeylanicum) is native to Sri Lanka. Cinnamon wood is discarded as firewood, making it an ideal candidate as a locally available low cost adsorbent for Cu2+.Item Determination of antioxidant activity, phenolic content and pH in wine prepared from local beet(Institute of Chemistry Ceylon, 2019-05) Gunasekara,S.R; Udawatte,C.S; Weliwegamage,U.S.KBeetroot (Beta Vulgaris) is a vegetable containing high amounts of biologically active compounds such as antioxidants, and polyphenols. It also contains vitamin C, fiber, inorganic nitrogen and anthocyanin, which have various health benefits. In this study, wine was prepared by fermenting beet, and the antioxidant activity, pH and total phenolic content of the wine was determined.Item T he inhibition of acetylcholinesterase via synthetically viable coumarin derivatives(Institute of Chemistry Ceylon, 2018-05) Azeem,A; Ratnaweera, C; Udawatte,C.SAcetylcholinesterase is a serine hydrolase responsible for the hydrolysis of acetylcholine. The reversible inhibition of acetylcholinesterase can be useful in combating Alzheimer’s disease (AD). A computational study of the inhibition of acetylcholinesterase was conducted by performing Molecular Docking using a series of coumarin analogs generated by fragment based drug design methods.