A computational study on the inhibition of MCL-1 anti-apoptotic protein to activate apoptosis in cancer cells via commercially available natural product derivatives
No Thumbnail Available
Date
2019-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Institute of Chemistry Ceylon
Abstract
Bcl-2, BCL-XL and MCL-1 (Myeloid cell leukemia-1) are important anti-apoptotic proteins. The objective of this research was to identify commercially available natural product derivatives to inhibit MCL-1. Ligands were obtained from the ZINC12 database which provides 30793 chemically modified, commercially available natural product derivatives.
Description
Technical Sessions : A - 32
Page 39
Keywords
natural product, anti-apoptotic protein, Crystal structures