Altering bioavailability in curcumin derivatives- an in silico study

Abstract

Curcumin and its derivatives exhibit diverse pharmacological activities, including antioxidant, anti-inflammatory, anti-proliferative, antibacterial, analgesic, and antiviral effects. However, their therapeutic potential is often limited by poor bioavailability, primarily due to low intestinal absorption. In this in silico study, we screened 198 curcumin derivatives identified in previous studies for toxicological profiles, bioavailability, and drug-likeness.