A computational study on the inhibition of MCL-1 anti-apoptotic protein to activate apoptosis in cancer cells via commercially available natural product derivatives

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dc.contributor.authorCosta,M.S.V
dc.contributor.authorRatnaweera,C.N
dc.contributor.authorUdawatte,C.S
dc.date.accessioned2025-02-25T03:16:49Z
dc.date.available2025-02-25T03:16:49Z
dc.date.issued2019-05
dc.descriptionTechnical Sessions : A - 32 Page 39
dc.description.abstractBcl-2, BCL-XL and MCL-1 (Myeloid cell leukemia-1) are important anti-apoptotic proteins. The objective of this research was to identify commercially available natural product derivatives to inhibit MCL-1. Ligands were obtained from the ZINC12 database which provides 30793 chemically modified, commercially available natural product derivatives.
dc.identifier.urihttps://dr.ichemc.ac.lk/handle/123456789/326
dc.language.isoen
dc.publisherInstitute of Chemistry Ceylon
dc.relation.ispartofseries36; 2
dc.subjectnatural product
dc.subjectanti-apoptotic protein
dc.subjectCrystal structures
dc.titleA computational study on the inhibition of MCL-1 anti-apoptotic protein to activate apoptosis in cancer cells via commercially available natural product derivatives
dc.typeArticle

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