Conference Abstracts
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Item A chemometric study on the effect of feedstock choice and pyrolysis conditions on biochar production and its influence on the remediation of pharmaceuticals from aqueous solutions(Institute of Chemistry Ceylon, 2021-06) Fernando,Sachin; Peiris,Chathuri; Abeysundara,Sachith. P; Gunatilake,Sameera .RRemoval of antibiotics and non-steroidal antiinflammatory drugs (NSAIDs) from aqueous ecosystem is a serious concern due to their extensive usage and resulting the adverse effects on human and ecological health.Item A Comparison on Composition of Rain in Selected Locations in Colombo and Gampaha Districts(Institute of Chemistry Ceylon, 2022-06) Pieris,K. A. H; Poornima, W. V. D. S; Liyandeniya,A. B; Deeyamulla,M. P; Priyantha,NExpansion of industrial processes significantly contribute to the extent of atmospheric deposition, and hence, quantitative determination of the atmospheric quality through monitoring rainwater quality parameters is important for understanding the transport and fate of chemical species in the atmosphere.Item A Computational Approach to Determine the Potential Inhibition of the Gomesin Peptide as an AKT1 Inhibitor in Breast Cancer(Institute of Chemistry Ceylon, 2023-06) Senapathi Tharindu; Selvaraj, Saranya; Weerasinghe, and LaksiriAnimal trials and in vitro drug screening can improve drug discovery. However, such pre-clinical screenings are often costly and time-consuming. Due to this, a more effective technique is developed using in silico method for the same.Item A Computational Study of Cyclin-dependent Kinases 1 (CDK1) butyrolactone I complex and the Role of Mg Ion in the Active Site(Institute of Chemistry Ceylon, 2021-06) Jayawardana,Chanikya .D; Ratnaweera,Chinthaka. NCyclin-dependent kinases (CDK) 1, 2, 4, and 6 are the protein kinases that play a pivotal role in the cell cycle regulating of all eukaryotic organisms by phosphorylating proteins needed during the cell division cycle.Item A computational study on the inhibition of MCL-1 anti-apoptotic protein to activate apoptosis in cancer cells via commercially available natural product derivatives(Institute of Chemistry Ceylon, 2019-05) Costa,M.S.V; Ratnaweera,C.N; Udawatte,C.SBcl-2, BCL-XL and MCL-1 (Myeloid cell leukemia-1) are important anti-apoptotic proteins. The objective of this research was to identify commercially available natural product derivatives to inhibit MCL-1. Ligands were obtained from the ZINC12 database which provides 30793 chemically modified, commercially available natural product derivatives.Item A novel immunoanalytical method for obesity biomarker detection using antibody functionalized silver nanoparticles(Institute of Chemistry Ceylon, 2019-05) Abeysinghe,A.A.D.T; Sirimuthu,N.M.S; Perera,P.P.RObesity is a serious health issue related with increased body fat content. Escalating numbers of patients have been reported worldwide throughout the recent past, associated with a high cost in the healthcare sector. Other than being a disease condition by itself, it also acts as a risk factor for many metabolic and cardiovascular diseases.Item A preliminary study on green synthesis of silver nanoparticles using Annona glabra leaf extract(Institute of Chemistry Ceylon, 2019-05) Sithara,W. S; Wickramarachchi,S; De Silva,C. R; Aberathna,A. A. A .U; Amarasinghe,L .DIn this study, an eco-friendly, simple, rapid and a cost effective biological method for reducing Ag+ ions into silver nanoparticles (AgNPs) using the leaf extract of Annona glabra (A. glabra) plant has been developed. Although a number of plant extract mediated synthesis of AgNPs have been reported in the literature no previous attempt has been made on the use of A. glabra in the green synthesis of AgNPs.Item A study on complexation, stoichiometry and binding of selected anionic organic pollutants and protonated polyaza macrocycles(Institute of Chemistry Ceylon, 2021-06) Kumarasinghe ,Danushka. M; Fernando,Isurika RAnionic organic pollutants (AOPs) generated by industrial and laboratory processors are accumulated in the environment while causing health problems for human beings.Item A study on host-guest complexation of octaprotonated octaaza macrocycles with selected PAHs towards the template-directed synthesis of mechanically interlocked molecules(Institute of Chemistry Ceylon, 2023-06) Lekamge,Damith.D; Fernando,Isurika. RTemplate-directed synthesis (TDS) is one of the commonly used strategies in synthesis of mechanically interlocked molecules (MIMs). Inclusion complexes (ICs) of electron-deficient cationic macrocyclic ‘host’ and electron-rich ‘guest’ molecules have been used as donor-acceptor interactions driven ‘templates’ in TDS of MIMs.Item A study on the use of Bathophenanthroline as a fluorescence sensor for iron(II)(Institute of Chemistry Ceylon, 2019-05) Perera,P.P.P; De Costa,M D P; Senthilnithy,RAlthough Fe2+ is present as a trace element, it plays a vital role in living systems. Therefore measurement of trace amounts of Fe2+ is very important for many biological and ecological studies. Bathophenanthroline (BPhen) forms a stable 1:3 red color complex with Fe2+ and appears as a promising colorimetric probe for Fe2+. Using colorimetry, it has been possible to detect 10 parts of Fe2+ in 109 parts of water (540 nM).1,2Item Acetylcholinesterase inhibitory activity of Psychotria sarmentosa, Olax zeylanica and Hoya ovalifolia(Institute of Chemistry Ceylon, 2022-06) De Silva,W. S; Wijayarathna, C. D; De Silva,H. I. CAlzheimer’s disease is the most prevailing neurodegenerative disease and is becoming one of the major human health concerns today. Medicinal plants are known to produce a broad range of bioactive compounds and thus become an excellent source for the discovery of novel anti-acetylcholinesterase active drugs.Item Acute and subacute toxicity studies of the ethyl acetate soluble proanthocyanidins of immature inflorescence of Cocos nucifera L. in Wistar rats(Institute of Chemistry Ceylon, 2019-05) Ekanayake,C.P; Thammitiyagodage,M.G; Padumadasa,S; Seneviratne,B; Padumadasa,C; Abeysekera,A.MThe coconut palm, Cocos nucifera L. is a member of the monocotyledonous family, Arecaceae and mainly grows in tropical coastal areas. Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagiaItem Adsorptive removal of cadmium in aqueous solutions using coconut dregs residue as the adsorbent(Institute of Chemistry Ceylon, 2018-05) Perera,C Madawala, ARapid industrialization has contributed to the release of toxic heavy metals into natural water bodies giving rise to water pollution which has become a serious concern all over the world due to the non-biodegradable nature of heavy metals. Removal of heavy metals by utilizing the technique of adsorption using biological waste is an effective alternative.Item Adsorptive removal of Co(II) in aqueous solutions using Strychnos potatorum seed powder(Institute of Chemistry Ceylon, 2019-05) Ranaweera,K. H; Perera,B. AContamination of natural water bodies due to improper discharge of heavy metals has become a worldwide environmental problem. Development of low cost adsorbent materials for the removal of heavy metals, utilizing the technique of adsorption is an effective solution to this problem.Item Agro-waste mediated nanomaterials for potential applications(Institute of Chemistry Ceylon, 2023-06) Thiripuranathar GobikaItem Antioxidant activity and extraction kinetics of polyphenols in BOPF grade black tea (Camellia sinensis) from different geographical elevations in Sri Lanka(Institute of Chemistry Ceylon, 2018-05) Soysa,P; Wijesinghe, K MTea processed from young leaves and buds of Camellia sinensis is one of the most widely consumed beverages in the world due to its beneficial health effects. Tea grown in Sri Lanka are categorized as high grown (HGT), mid grown (MGT) and low grown tea (LGT) based on the geographical elevation of tea cultivation regionsItem Antioxidant and antimicrobial activity of flower and leaf extracts of Calotropis gigante(Institute of Chemistry Ceylon, 2024-06) Kumari ,P.K.R.S; Edirisinghe,E.M.R.K.BCalotropis gigantea is latex bearing medicinal plant belonging to the family Apocynaceae. Two forms of C. gigantea; white-flowered form and purple-flowered form can be found native to Sri Lanka.Item Antioxidant Properties of Selected Hela Suwaya Herbal Porridge(Institute of Chemistry Ceylon, 2021-06) Randiligama,Bismi Thisaruka; Ekanayake,SagarikaHerbal porridges that contain high amounts of plant materials are rich sources of antioxidants. These are made by incorporating rice, different leaf extracts and coconut milk. Commercial availability of easy to prepare porridges is currently a trend due to the lifestyle changes of people.Item Application of green synthesized palladium nanoparticles using banana leaf extract in Suzuki cross-coupling reaction(Institute of Chemistry Ceylon, 2019-05) Dantanarayana,S.O.A; De Silva,H.I.CApplication of plant extract-based nanoparticles in organic synthesis has become an emerging field today due to its biocompatibility, eco-friendliness and cost efficiency.1,2 The objectives of the present study were to develop an elementary and ecological method to synthesize palladium nanoparticles (Pd NPs) using extracts of banana leaves, which is a commonly found agro-waste in Sri Lanka, and investigate the catalytic activity of the synthesized Pd NPs in Suzuki crosscoupling reactions.Item Binding interactions of coumarin derivatives with Hodgkin’s disease related protein ADAM-10; an in-silico approach(Institute of Chemistry Ceylon, 2019-05) Thilakarathne,N.M. H. N; Udawatte,C. S; Rathnaweera,C .NHodgkin’s disease is a malignant tumor which is one of the most common cancers among the elderly and children. It is characterized by the overexpression of ADAM-10 protein with increased release of NKG2D ligand which causes impaired immune response against tumor cells.1