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Item Binding interactions of coumarin derivatives with Hodgkin’s disease related protein ADAM-10; an in-silico approach(Institute of Chemistry Ceylon, 2019-05) Thilakarathne,N.M. H. N; Udawatte,C. S; Rathnaweera,C .NHodgkin’s disease is a malignant tumor which is one of the most common cancers among the elderly and children. It is characterized by the overexpression of ADAM-10 protein with increased release of NKG2D ligand which causes impaired immune response against tumor cells.1Item Synthesis and characterization of graphene oxide coated silica nanoparticles(Institute of Chemistry Ceylon, 2019-05) Weerasinghe,M. A .S .N; Liyanage,J .A; Kumarasinghe,A .RGraphene oxide (GO) is capable of absorbing many common pollutants of water such as heavy metals and organic contaminants. However, graphene oxide membranes easily disintegrate in water and aggregates. T his decreases its adsorption capacity and diminishes its practical applications. Therefore, to prevent the above problems graphene oxide is combined with silica nanoparticles.Item Fabrication and characterization of water stable multi-layer graphene oxide membranes by potassium ion crosslinking(Institute of Chemistry Ceylon, 2019-05) Bandara,W. R. N. M; Liyanage,J. A; Kumarasinghe,A. RGraphene Oxide (GO) was synthesized from vein graphite sourced from Bogala mine using Improved Hummer’s method. GO nano sheets are the oxidative exfoliation products of graphite. GO contains oxygenated functional groups attached to their basal planes and edges.Item DFT study on classical Koshland retention mechanism of Linamarin hydrolysis(Institute of Chemistry Ceylon, 2019-05) Dinuka,D. L. S; Ratnaweera,C. NT he hydrolysis of glucosidic linkage catalyzed by every carbohydrate-hydrolase is a reaction in which the product retains (α→α or β→β) or inverts (α→β or β→α) the anomeric configuration of the substrate. By releasing α-glucose and β-glucose, respectively, from the common substrates having α or β -glucosidic linkages, α-glucosidase and β-glucosidase are essentially distinguished.Item A study on the use of Bathophenanthroline as a fluorescence sensor for iron(II)(Institute of Chemistry Ceylon, 2019-05) Perera,P.P.P; De Costa,M D P; Senthilnithy,RAlthough Fe2+ is present as a trace element, it plays a vital role in living systems. Therefore measurement of trace amounts of Fe2+ is very important for many biological and ecological studies. Bathophenanthroline (BPhen) forms a stable 1:3 red color complex with Fe2+ and appears as a promising colorimetric probe for Fe2+. Using colorimetry, it has been possible to detect 10 parts of Fe2+ in 109 parts of water (540 nM).1,2Item Complexation between Fe2+ and 1,10-Phenanthrolin-5-amine and the quenching mechanism(Institute of Chemistry Ceylon, 2019-05) Wijesekera,G. I. P; De Costa,M.D. P; Senthilnithy,R1,10-Phenanthroline and its derivatives are very important chelating bidentate ligands for transition metal ions.1 From previous studies, it has been investigated that Fe2+ make stable complexes with 1,10-Phenanthroline and its derivatives.2Item Durian and rambutan peels as potential sources of antioxidants(Institute of Chemistry Ceylon, 2019-05) Silva,A.A.G; Wickramaarachchi,S; Attanayake,R.N; Rajapakse,C .S .KRambutan (Nephelium lappaceum L.) and Durian (Durian zibethinus Murr.) are popular seasonal fruits grown in tropical countries, enriched in varieties of phytochemicals.1, 2 However, peels of these fruits cause unpleasant odors and serious environmental problems.Item Cytotoxic potential and apoptotic effect of Barringtonia asiatica seed kernel against HepG2 cell line(Institute of Chemistry Ceylon, 2019-05) Paramasamy,R; Ekanayake,S; Samarakoon,S.RLiver cancer causes significant morbidity and mortality among humans worldwide due to lack of effective therapeutic strategies for control and treatment. According to World Health Organization, 7.5 % of male deaths in Sri Lanka are due to liver cancer and mortality rate due to liver cancer is increasing each year1.Item Plumbagin functionalized silver nanoparticles for potential antimicrobial applications(Institute of Chemistry Ceylon, 2019-05) Dammulla,I.N; Bogahawatta,L .B. A. E; Gunasekara,C. P; Weerasekara,M. M; Padumadasa,C; Sirimuthu,N. M. SPlumbago indica L. called “Rathnitul” in Sinhala is a medicinal plant belonging to the family Plumbaginaceae that is extensively used in the traditional system of medicine in Sri Lanka.Item Chemical and microbiological contaminants and preservatives in commercially available tomato sauces(Institute of Chemistry Ceylon, 2019-05) Iqbal,F.N; Somapala,E. G; Perera,M; Deraniyagala,S.PTomato sauces are a part of the processed food industry which is currently amongst the fastest growing both for consumption and export making it a highly profitable industry. The present work was aimed to determine microbiological and some chemical parameters of commercially available tomato sauces.Item Determination of microbiological and chemical parameters of ready-to-serve fruit drinks and carbonated beverages commercially available in Sri Lanka(Institute of Chemistry Ceylon, 2019-05) Radiyya,F.L; Somapala.E.G; Perera,M; Deraniyagala,S.PItem Determination of antioxidant activity, phenolic content and pH in wine prepared from local beet(Institute of Chemistry Ceylon, 2019-05) Gunasekara,S.R; Udawatte,C.S; Weliwegamage,U.S.KBeetroot (Beta Vulgaris) is a vegetable containing high amounts of biologically active compounds such as antioxidants, and polyphenols. It also contains vitamin C, fiber, inorganic nitrogen and anthocyanin, which have various health benefits. In this study, wine was prepared by fermenting beet, and the antioxidant activity, pH and total phenolic content of the wine was determined.Item Influence of volatiles from brinjal host on the attraction of brinjal fruit and shoot borer- Leucinodes orbonalis Guenee(Institute of Chemistry Ceylon, 2019-05) Nusra,M.S.F; Paranagama,P.A; Amarasinghe,L.D; Udukala,D.NBrinjal fruit and shoot borer, Leucinodes orbonalis Guenee, is a major pest on brinjal, Solanum melongena in South and South-East Asia. Larvae cause enormous damage to brinjal pods and shoots and the population management is normally done with frequent application of insecticides.Item Determination of the oxalate ion concentration in green leafy vegetables(2019-05) Liyanage,J.V; Jayasundara,U.KKidney and gall stone diseases occurring in the urinary tract can be life threatening and are promoted by the existence of oxalic acid (oxalate ion) in green leafy vegetables. Plants that accumulate large quantities of oxalic acid generally contain high concentrations of oxalate ions and salts.Item Microwave and open vessel digestion methods for biochar and activated carbon(Institute of Chemistry Ceylon, 2019-05) Wathudura,P.D; Peiris,C; Gunatilake,S.R; Kaumal,M.NActivated carbon (AC) and biochar (BC) are low cost carbonaceous adsorbent material widely used for the removal of toxic metal ions from aqueous systems due to their highly porous nature.Item Sorptive removal of p-nitroaniline from aqueous matrices by using acid modified tea waste biochar(Institute of Chemistry Ceylon, 2019-05) Block,Y.D; Dissanayake,B; Peiris,C; Gunathilake,S.RPara-Nitroaniline (PNA) is one of the most widely used synthetic precursors in the pharmaceutical industry which has been identified as a contaminant of emerging concern (CEC) due to its toxicity. Slow pyrolyzed teawaste biochar (BC), modified by shaking with 5M hydrochloric acid for 24 h at 50±5 °C, was used for the sorptive removal of PNA from aqueous systems.Item Spectrophotometric determination of nitrite content in processed chicken products(Institute of Chemistry Ceylon, 2019-05) Somarathne,W. R. P; Chilki, K. K. D; Jayatissa,R. M. K. P; Nishadya,S. M. S; Anuththara, G. V. D; Illangakoon,M. S. A; Somapala,E. G; Udawatte,C. SNitrites are used as preservatives in processed meat. Although they are beneficial and safe at permitted levels, they can be carcinogenic when used in excess. Large doses of nitrites can also lead to a condition known as methemoglobinemia. The aim of this study is to determine whether the nitrite content in four locally available brands of processed chicken products are within the permitted levels.Item Cinnamon wood as an adsorbant for the removal of Cu2+ from aqueous solutions(Institute of Chemistry Ceylon, 2019-05) Wijesekara,D.N; Udawatte,C.SHeavy metal water pollution remains one of the most harmful ecological and health issues globally, and Cu2+ is a common pollutant found in water bodies. Cinnamon (Cinnamomum verum or Cinnamomum zeylanicum) is native to Sri Lanka. Cinnamon wood is discarded as firewood, making it an ideal candidate as a locally available low cost adsorbent for Cu2+.Item Adsorptive removal of Co(II) in aqueous solutions using Strychnos potatorum seed powder(Institute of Chemistry Ceylon, 2019-05) Ranaweera,K. H; Perera,B. AContamination of natural water bodies due to improper discharge of heavy metals has become a worldwide environmental problem. Development of low cost adsorbent materials for the removal of heavy metals, utilizing the technique of adsorption is an effective solution to this problem.Item A preliminary study on green synthesis of silver nanoparticles using Annona glabra leaf extract(Institute of Chemistry Ceylon, 2019-05) Sithara,W. S; Wickramarachchi,S; De Silva,C. R; Aberathna,A. A. A .U; Amarasinghe,L .DIn this study, an eco-friendly, simple, rapid and a cost effective biological method for reducing Ag+ ions into silver nanoparticles (AgNPs) using the leaf extract of Annona glabra (A. glabra) plant has been developed. Although a number of plant extract mediated synthesis of AgNPs have been reported in the literature no previous attempt has been made on the use of A. glabra in the green synthesis of AgNPs.